PathwayDB: a proteolytic pathway database
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  • #15: Proteolytic cascade in human blood coagulation system
    Proteolytic cascade in human blood coagulation system. Blood coagulation is a defense mechanism which prevent bleeding due to vessel damage by plug formation at the injury site. Any perturbation of the coagulation cascade can result in uncontrolled clotting or hemorrhage. The delicate regulatory system is controlled by a number of plasma protein-protein interactions as well as interaction with cellular receptors. Here, we present a primary blood coagulation model which is based on absolute minimal transformations involved in the process. The current model comprises of an extended set(108 in number) of molecular species and complexes. The model can be freely downloaded and used for further user specific investigation.
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  • Created on: Fri Sep 12 09:58:09 PDT 2008
  • Created by: ptalwar