CutDB: a proteolytic event database
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  • Number of proteolytic events found : 40
  • Display mode: Flexibility of connection: Steps of expanding:
  • Events created with ID=24702 or lower, will be used in reconstruction.
  • ID Protease Organism [protease] Substrate Organism [substrate] Cut-site Structure Update Detail
    memapsin-1A01.041 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens KLVF-FAED
    690-691
    Detail
    memapsin-1A01.041 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens LVFF-AEDV
    691-692
    Detail
    caspase-6C14.005 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens VKMD-AEFR
    672-673
    Detail
    caspase-3 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens VEVD-AAVT
    739-740
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens LVFF-AEDV
    691-692
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens KLVF-FAED
    690-691
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens TYKF-FEQM
    764-765
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens IIGL-MVGG
    705-706
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens IVIT-LVML
    719-720
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens VITL-VMLK
    720-721
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens VVIA-TVIV
    713-714
    Detail
    cathepsin DA01.009 Homo sapiens APP
    Amyloid beta a4 protein precursor, isoform a
    Homo sapiens VIAT-VIVI
    714-715
    Detail
    presenilin 1A22.001 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens GGVV-IATV
    711-712
    Jun 12
    2006
    YI
    Detail
    presenilin 1A22.001 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VVIA-TVIV
    713-714
    Jun 12
    2006
    YI
    Detail
    memapsin-2A01.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens EVKM-DAEF
    671-672
    Jan 09
    2007
    YI
    Detail
    matrix metallopeptidase-9M10.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens HHQK-LVFF
    687-688
    Jun 30
    2006
    Svetlana
    Detail
    membrane-type matrix metallopeptidase-3M10.016 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens RVEA-MLND
    463-464
    Jun 12
    2006
    YI
    Detail
    membrane-type matrix metallopeptidase-3M10.016 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VLAN-MISE
    579-580
    Jun 12
    2006
    YI
    Detail
    membrane-type matrix metallopeptidase-3M10.016 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens QPWH-SFGA
    622-623
    Jun 12
    2006
    YI
    Detail
    membrane-type matrix metallopeptidase-3M10.016 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens EVHH-QKLV
    685-686
    Jun 12
    2006
    YI
    Detail
    membrane-type matrix metallopeptidase-1M10.014 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VLAN-MISE
    579-580
    Jul 21
    2009
    SG
    Detail
    presenilin 1A22.001 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VIAT-VIVI
    714-715
    Jun 12
    2006
    YI
    Detail
    ADAM10 peptidaseM12.210 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens HHQK-LVFF
    687-688
    Jan 10
    2007
    YI
    Detail
    ADAM10 peptidaseM12.210 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens DSGY-EVHH
    681-682
    Jun 12
    2006
    YI
    Detail
    ADAM10 peptidaseM12.210 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VHHQ-KLVF
    686-687
    Jun 12
    2006
    YI
    Detail
    matrix metallopeptidase-9M10.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens LVFF-AEDV
    691-692
    Jun 30
    2006
    Svetlana
    Detail
    matrix metallopeptidase-9M10.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens NKGA-IIGL
    701-702
    Jun 30
    2006
    Svetlana
    Detail
    matrix metallopeptidase-9M10.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens AIIG-LMVG
    704-705
    Jun 30
    2006
    Svetlana
    Detail
    matrix metallopeptidase-9M10.004 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens IIGL-MVGG
    705-706
    Jun 30
    2006
    Svetlana
    Detail
    ADAM9 peptidaseM12.209 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens HHQK-LVFF
    687-688
    Jan 10
    2007
    YI
    Detail
    caspase Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens DNVD-SADA
    197-198
    Dec 26
    2006
    YI
    Detail
    caspase Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens DYAD-GSED
    219-220
    Dec 26
    2006
    YI
    Detail
    caspase Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens VEVD-AAVT
    739-740
    Dec 26
    2006
    YI
    Detail
    beta-site APP-cleaving enzyme 1 Homo sapiens
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens EVKM-DAEF
    671-672
    Jan 07
    2007
    Svetlana
    Detail
    ADAM17 peptidaseM12.217 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens HHQK-LVFF
    687-688
    Apr 03
    2008
    Alex
    Detail
    eupitrilysinM16.009 Homo sapiens APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens LVFF-AEDV
    691-692
    Feb 25
    2009
    SG
    Detail
    memapsin-2A01.004 Mus musculus APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens EVPT-DGNA
    22-23
    Sep 18
    2008
    Isola
    Detail
    memapsin-2A01.004 Mus musculus APP
    amyloid beta A4 protein precursor, isoform a
    Homo sapiens GLLA-EPQR
    30-31
    Sep 18
    2008
    Isola
    Detail
    HIV-1 retropepsinA02.001 human immunodeficiency virus 1 APP
    amyloid beta A4 protein isoform a precursor
    Homo sapiens VEVA-EEEE
    229-230
    Jun 10
    2009
    SG
    Detail
    HIV-1 retropepsinA02.001 human immunodeficiency virus 1 APP
    amyloid beta A4 protein isoform a precursor
    Homo sapiens LPVN-GEFS
    610-611
    Jun 10
    2009
    SG
    Detail