CutDB: a proteolytic event database
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    • This_entry_is_based_on_an_experiment.
    Substrate
    Definition: heparanase
    Symbol: HPSE
    Organism: Homo sapiens
    NCBI Accession: CAL91960
    SubstrateDB: 26531
    [Sequence on/off]
    MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPR
    FLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKL
    RLEWPYQEQLLLREHYQKKFKNSTYSKPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDV
    GQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATREDFLNPDVLDIFISSVQKVFQVVESTRPGKK
    VWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSL
    LFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKY
    LLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
    ....:....1....:....2....:....3....:....4....:....5....:....6....:....7
    Cut-site
    Sequence: PYQE-QLLL
    Position: 148-149
    Protease
    Definition: cathepsin L
    Organism: Homo sapiens
    MEROPS ID: MER000622
    PMAP ID: pmap.20723
    MEROPS code: C01.032
    Consequence
    Activation_complete
    Disease
    Cancer
    Method_of_ID
    Mass spectrometry
    Original citation
    Comments and others